Genetic Scissors for Tailored Neuroscience Solutions

By making it possible to “surgically” act on DNA, the CRISPR-Cas9 system is not only revolutionizing genome editing techniques, it is paving the way for new and exciting ways to study the brain. CRISPR-Cas9. This barbaric acronym hides a revolutionary process: the modification of a gene or its replacement by another. However simple it may seem, this method is nevertheless the result of nearly thirty years of research. CRISPR-Cas9 (pronounced “crisper”) operates like genetic scissors: it targets a specific region of the DNA, cuts it out and inserts a desired sequence in its place. CRISPR-Cas9 is a complex made up of two elements: on the one hand, an RNA strand with a sequence that is homologous with the DNA to be excised, and on the other a nuclease enzymeFermerEnzyme capable…

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