Machine Learning Meta-analysis of Large Metagenomic Datasets

Introduction The human microbiome constitutes the whole set of microbial organisms associated with the human host. It has been shown to be crucial for human health and for the development and maintenance of the immune system and for several metabolic activities [1–3]. Significant effort has been devoted to its characterization in healthy individuals and subjects with a variety of diseases such as inflammatory bowel diseases [4,5], obesity [6,7], and type-2 diabetes [8]. Consequently, the potential use of the microbiome as a diagnostic tool is a promising line of investigation [9]. In addition, even when the findings are not immediately relevant for the clinical setting, identifying associations between the microbiome and specific diseases is essential for follow-up mechanistic studies. Next-generation DNA sequencing technologies permit comprehensive profiling of the microbial communities from…

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