Cerebrovascular disease is the leading cause of disability in adults and there is no effective treatment to avoid stroke damages after the first hours. Various types of engineered biomaterial matrices, which in combination with stem cells, have shown promises for brain tissue replacement and reduce post-stroke disability. Hydrogels are tree-dimensional cross-linked networks of water-soluble polymers. Hydrogel polymers can be engineered in a variety of physical forms. They have excellent nutrient and oxygen permeability, allowing cell survival in the scaffold. The advantage of this kind of biomaterial is injectable. The aim of this work is to optimize the cell therapy and to improve the stem cell engraftment by co-administration with hyaluronic acid hydrogel. For this purpose rats Sprague Dawley male were submitted to a model of ischemic stroke by occlusion of…

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